Review of Immune Checkpoint Inhibitors and Radiotherapy Related Skin Toxicities

Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, and their use in combination with radiation therapy (RT) has become increasingly utilized to optimize positive outcomes. The cutaneous adverse reactions from RT as well ICIs are both documented; however, these toxicities can be exacerbated. may work synergistically create an enhanced immune response against the tumor cells. This synergistic effect been reported occur locally at site of RT, systemically via abscopal effect. Fortunately, this treatment does not increase incidence reactions, although several cases skin toxicity RT. is thought ‘immunocompromised district’ or localized dysregulation irradiated skin. review summarizes previously published case reports discusses ICI therapy. Properly identifying induced depends on factors including patient history, sequence therapies, timing reaction, histological findings. Skin range severity include ICI-induced recall dermatitis, uncommon presentations Stevens-Johnson syndrome, lichen planus, bullous pemphigoid which within areas prior exposure. It important for oncologists dermatologists alike aware spectrum associated